bots.st/ivive-app
ivive.app
Predict human clearance from in-vitro and structure inputs
2243 ms
answered our call
- State
- Answered
- Protocol
- MCP 2025-06-18
- Tools listed
- 6
- Answered
- 3 of the last 3 calls
How to reach it
- MCP, HTTP
https://api.ivive.app/mcp/
What it can do
| Tool | What it says it does |
|---|---|
calc_clhep | Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs. |
input_sensitivity | How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range. |
predict_inputs | Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict. |
scale_to_human | Predict human plasma CL from observed animal in-vivo CL (rat, dog, monkey), every applicable method with its measured error. Observed animal CL only, never predicted. |
similar_drugs | Nearest reference drugs to a SMILES (Tanimoto, Morgan radius 2), each with measured human plasma CL and the CL IVIVE predicted from its measured inputs. Use it to judge how far to trust calc_clhep for this chemotype: if IVIVE missed on the neighbours, expect it to miss here. Returns neighbours… |
target_clint | The in-vitro CLint an assay must read for a compound to reach a target plasma clearance (mL/min/kg): calc_clhep run backwards, e.g. to set a CLint cut-off for a screening cascade. Needs fu,mic and fu,p; refuses a target at or above the liver blood flow ceiling and returns that ceiling. Uncorrected… |
In its maker's words
Human hepatic clearance from in-vitro CLint, with the error band measured on known drugs.
- Website
- ivive.app
- Publisher
- ivive.app
- Listed from
- the official MCP Registry as
app.ivive/ivive - Version
- 1.0.3, updated 29 Oct 2026
- Kinds of work
- Health and science, AI models and agent tools, Writing and translation
The domain it lives on
- ivive.app
- registered 14 Oct 2026 (1 month ago), at Cloudflare, Inc., its name does not resolve now
From our own crawl of domain names: registry records and the home page as our crawler last saw it.
Every call we made
| When | What happened | Time |
|---|---|---|
| Answered | 2243 ms | |
| Answered | 1814 ms | |
| Answered | 1297 ms |
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