bots.st/folklore-clinical-variant-interpretation-mcp
Folklore Clinical Variant Interpretation MCP
ACMG/AMP germline variant classifications
161 ms
answered our call
- State
- Answered
- Protocol
- MCP 2025-06-18
- Tools listed
- 11
- Answered
- 4 of the last 4 calls
How to reach it
- MCP, HTTP
https://api.helena.bio/folklore/v1/mcp
What it can do
| Tool | What it says it does |
|---|---|
classify_germline_variant | Classify one GRCh38 germline nuclear SNV or simple indel smaller than 50 bp under ACMG/AMP. Accepts genomic, coding or protein HGVS, coordinates, SPDI, rsID or a returned canonical key. Returns normalized identity, automated classification, applied criteria, ClinVar assertions, population… |
get_gene_disease_associations | Find diseases associated with an exact gene symbol or HGNC identifier. Returns ClinGen gene-disease validity assertions, relation-specific inheritance, source reports and snapshot provenance, including conflicting and limited assertions. |
get_gene_profile | Read the selected gene_id and immutable snapshot_id from resolve_gene. Returns overview, disease validity, dosage, mechanisms, transcripts, native assemblies, constraint, ClinVar summaries and consequences, expression, GWAS, phenotypes and protein/pathways with source assertions, coverage, count… |
get_gene_section | Read a gene-profile section using gene_id, snapshot_id and its returned opaque cursor. Returns source records, assembly/release, coverage, totals, count units and provenance. snapshot_unavailable requires a fresh resolution/profile request. |
get_publication_details | Retrieve one PMID from the PubMed-derived genetics corpus, including title, abstract, authors, journal, publication types, MeSH terms, gene and variant mentions, retraction status and PubMed/PMC links. |
resolve_gene | Resolve a human gene symbol, previous symbol, alias, HGNC, Ensembl or NCBI Gene identifier. Returns exact, alias, ambiguous, not_found or withdrawn status with candidates and identity_snapshot_id. Use a selected HGNC gene_id and snapshot_id with get_gene_profile. Gene-plus-HGVS and variant… |
search_disease_genes | Find genes associated with an exact MONDO identifier or disease-name search. Returns ClinGen validity assertions with inheritance, source reports and snapshot provenance. Name searches can return multiple disease identities. |
search_gene_literature | Retrieve a live publication capture for a resolved gene_id and snapshot_id. Returns source links, match labels, capture time/hash, degradation and gene/snapshot/sort-bound cursors. This capture is separate from the immutable reference snapshot and contains no abstracts. |
search_literature_corpus | Search the genetics Literature Corpus by question, PMID, DOI, PMCID, gene, variant, phenotype, HPO or OMIM concept. Known publication identifiers provide exact anchors. Returns ranked publications, match types, scores and source links. |
search_variant_literature | Resolve one GRCh38 germline variant and retrieve publications from the PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Returns match types, source links, corpus provenance and retrieval time. |
support_helena | Retrieve Helena Good campaign, rules, manifest and MCP connection URLs. |
In its maker's words
Germline ACMG/AMP classification, genes, disease associations, literature and API-key case analysis.
- Website
- folklore.helena.bio
- Source
- github.com/helena-bioinformatics/folklore-mcp
- Publisher
- helena-bioinformatics (4 listings in the registry)
- Listed from
- the official MCP Registry as
io.github.helena-bioinformatics/folklore - Version
- 2.0.0, updated 5 Nov 2026
- Kinds of work
- AI models and agent tools, Health and science, Law, tax and government
The domain it lives on
- helena.bio
- registered 10 Nov 2025 (12 months ago), at NAMECHEAP INC, its home page is a working site
From our own crawl of domain names: registry records and the home page as our crawler last saw it.
Every call we made
| When | What happened | Time |
|---|---|---|
| Answered | 161 ms | |
| Answered | 160 ms | |
| Answered | 173 ms | |
| Answered | 173 ms |
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